2bzf: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /> <applet load="2bzf" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bzf, resolution 2.87Å" /> '''STRUCTURAL BASIS FO... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2bzf.gif|left|200px]]<br /> | [[Image:2bzf.gif|left|200px]]<br /><applet load="2bzf" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2bzf" size=" | |||
caption="2bzf, resolution 2.87Å" /> | caption="2bzf, resolution 2.87Å" /> | ||
'''STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)'''<br /> | '''STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)'''<br /> | ||
==Overview== | ==Overview== | ||
The ability of barrier-to-autointegration factor (BAF) to bind and bridge | The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation. | ||
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
2BZF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2BZF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZF OCA]. | ||
==Reference== | ==Reference== | ||
| Line 17: | Line 16: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bradley, C | [[Category: Bradley, C M.]] | ||
[[Category: Craigie, R.]] | [[Category: Craigie, R.]] | ||
[[Category: Dyda, F.]] | [[Category: Dyda, F.]] | ||
[[Category: Ghirlando, R.]] | [[Category: Ghirlando, R.]] | ||
[[Category: Ronning, D | [[Category: Ronning, D R.]] | ||
[[Category: dna compaction]] | [[Category: dna compaction]] | ||
[[Category: lem family]] | [[Category: lem family]] | ||
| Line 28: | Line 27: | ||
[[Category: retroviral integration]] | [[Category: retroviral integration]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:17 2008'' | ||
