1yit: Difference between revisions

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[[Image:1yit.gif|left|200px]]
{{Seed}}
[[Image:1yit.png|left|200px]]


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{{STRUCTURE_1yit|  PDB=1yit  |  SCENE=  }}  
{{STRUCTURE_1yit|  PDB=1yit  |  SCENE=  }}  


'''Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui'''
===Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui===




==Overview==
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Crystal structures of H. marismortui large ribosomal subunits containing the mutation G2099A (A2058 in E. coli) with erythromycin, azithromycin, clindamycin, virginiamycin S, and telithromycin bound explain why eubacterial ribosomes containing the mutation A2058G are resistant to them. Azithromycin binds almost identically to both G2099A and wild-type subunits, but the erythromycin affinity increases by more than 10(4)-fold, implying that desolvation of the N2 of G2099 accounts for the low wild-type affinity for macrolides. All macrolides bind similarly to the H. marismortui subunit, but their binding differs significantly from what has been reported in the D. radioidurans subunit. The synergy in the binding of streptogramins A and B appears to result from a reorientation of the base of A2103 (A2062, E. coli) that stacks between them. The structure of large subunit containing a three residue deletion mutant of L22 shows a change in the L22 structure and exit tunnel shape that illuminates its macrolide resistance phenotype.
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{{ABSTRACT_PUBMED_15851032}}


==About this Structure==
==About this Structure==
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[[Category: Virginiamycin m]]
[[Category: Virginiamycin m]]
[[Category: Virginiamycin s]]
[[Category: Virginiamycin s]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:06:09 2008''

Revision as of 12:06, 28 July 2008

File:1yit.png

Template:STRUCTURE 1yit

Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui

Template:ABSTRACT PUBMED 15851032

About this Structure

1YIT is a Protein complex structure of sequences from Haloarcula marismortui. Full crystallographic information is available from OCA.

Reference

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance., Tu D, Blaha G, Moore PB, Steitz TA, Cell. 2005 Apr 22;121(2):257-70. PMID:15851032

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