1ykb: Difference between revisions

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[[Image:1ykb.gif|left|200px]]
{{Seed}}
[[Image:1ykb.png|left|200px]]


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{{STRUCTURE_1ykb|  PDB=1ykb  |  SCENE=  }}  
{{STRUCTURE_1ykb|  PDB=1ykb  |  SCENE=  }}  


'''Crystal Structure of Insect Cell Expressed IL-22'''
===Crystal Structure of Insect Cell Expressed IL-22===




==Overview==
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The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.
The line below this paragraph, {{ABSTRACT_PUBMED_15983417}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15983417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15983417}}


==About this Structure==
==About this Structure==
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[[Category: Il-22]]
[[Category: Il-22]]
[[Category: Interleukin]]
[[Category: Interleukin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:25:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:23:49 2008''
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