1ymz: Difference between revisions

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[[Image:1ymz.gif|left|200px]]
{{Seed}}
[[Image:1ymz.png|left|200px]]


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{{STRUCTURE_1ymz|  PDB=1ymz  |  SCENE=  }}  
{{STRUCTURE_1ymz|  PDB=1ymz  |  SCENE=  }}  


'''CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis'''
===CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis===




==Overview==
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Classical studies show that for many proteins, the information required for specifying the tertiary structure is contained in the amino acid sequence. Here, we attempt to define the sequence rules for specifying a protein fold by computationally creating artificial protein sequences using only statistical information encoded in a multiple sequence alignment and no tertiary structure information. Experimental testing of libraries of artificial WW domain sequences shows that a simple statistical energy function capturing coevolution between amino acid residues is necessary and sufficient to specify sequences that fold into native structures. The artificial proteins show thermodynamic stabilities similar to natural WW domains, and structure determination of one artificial protein shows excellent agreement with the WW fold at atomic resolution. The relative simplicity of the information used for creating sequences suggests a marked reduction to the potential complexity of the protein-folding problem.
The line below this paragraph, {{ABSTRACT_PUBMED_16177782}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16177782}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMZ OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMZ OCA].  


==Reference==
==Reference==
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[[Category: Artificial protein]]
[[Category: Artificial protein]]
[[Category: Computational design]]
[[Category: Computational design]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:31:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:35:32 2008''

Revision as of 02:35, 28 July 2008

File:1ymz.png

Template:STRUCTURE 1ymz

CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis

Template:ABSTRACT PUBMED 16177782

About this Structure

Full experimental information is available from OCA.

Reference

Evolutionary information for specifying a protein fold., Socolich M, Lockless SW, Russ WP, Lee H, Gardner KH, Ranganathan R, Nature. 2005 Sep 22;437(7058):512-8. PMID:16177782

Page seeded by OCA on Mon Jul 28 05:35:32 2008

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