12iv: Difference between revisions
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==CryoEM structure of monoclonal Fab 047-09 1A02 binding the lateral patch of influenza virus H1 HA (A/California/04/2009 H1N1)== | |||
<StructureSection load='12iv' size='340' side='right'caption='[[12iv]], [[Resolution|resolution]] 3.76Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[12iv]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/04/2009(H1N1)) Influenza A virus (A/California/04/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=12IV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=12IV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.76Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[[Category: Fernandez-Quintero | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=12iv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=12iv OCA], [https://pdbe.org/12iv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=12iv RCSB], [https://www.ebi.ac.uk/pdbsum/12iv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=12iv ProSAT]</span></td></tr> | ||
[[Category: Han | </table> | ||
[[Category: Ward | == Function == | ||
[https://www.uniprot.org/uniprot/C3W5S1_I09A0 C3W5S1_I09A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Fernandez-Quintero ML]] | |||
[[Category: Han J]] | |||
[[Category: Ward AB]] | |||
Latest revision as of 16:13, 25 September 2026
CryoEM structure of monoclonal Fab 047-09 1A02 binding the lateral patch of influenza virus H1 HA (A/California/04/2009 H1N1)
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