31hy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 31hy is ON HOLD until Paper Publication~~

==Mycobacterium tuberculosis transcription termination factor Rho in complex with an RNA substrate bound to the secondary binding site and the ATP analogue ADP-BeF3==

~~Authors: Weixlbaumer, A., Saint-Andre, C.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[31hy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=31HY OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=31HY FirstGlance].

~~Description:~~ Mycobacterium tuberculosis transcription termination factor Rho in complex with an RNA substrate bound to the secondary binding site and the ATP analogue ADP-BeF3

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: Saint-Andre, C]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=31hy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=31hy OCA], [https://pdbe.org/31hy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=31hy RCSB], [https://www.ebi.ac.uk/pdbsum/31hy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=31hy ProSAT]</td></tr>

[[Category: Weixlbaumer, A]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/RHO_MYCTO RHO_MYCTO] Facilitates transcription termination from RNA polymerase (RNAP) by binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, translocation in a 5'-3' direction on the RNA (toward RNAP), and release of the RNA from the DNA template.[HAMAP-Rule:MF_01884] Plays a major role in reduction of R-loop formation across the genome; R-loops can be generated by annealing of untranslated (often antisense) RNA to upstream DNA.[HAMAP-Rule:MF_01884]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mycobacterium tuberculosis]]

[[Category: Saint-Andre C]]

[[Category: Weixlbaumer A]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 31hy is ON HOLD  until Paper Publication
+==Mycobacterium tuberculosis transcription termination factor Rho in complex with an RNA substrate bound to the secondary binding site and the ATP analogue ADP-BeF3==
+<StructureSection load='31hy' size='340' side='right'caption='[[31hy]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-Authors: Weixlbaumer, A., Saint-Andre, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[31hy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=31HY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=31HY FirstGlance]. <br>
-Description: Mycobacterium tuberculosis transcription termination factor Rho in complex with an RNA substrate bound to the secondary binding site and the ATP analogue ADP-BeF3
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Saint-Andre, C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=31hy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=31hy OCA], [https://pdbe.org/31hy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=31hy RCSB], [https://www.ebi.ac.uk/pdbsum/31hy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=31hy ProSAT]</span></td></tr>
-[[Category: Weixlbaumer, A]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RHO_MYCTO RHO_MYCTO] Facilitates transcription termination from RNA polymerase (RNAP) by binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, translocation in a 5'-3' direction on the RNA (toward RNAP), and release of the RNA from the DNA template.[HAMAP-Rule:MF_01884]  Plays a major role in reduction of R-loop formation across the genome; R-loops can be generated by annealing of untranslated (often antisense) RNA to upstream DNA.[HAMAP-Rule:MF_01884]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis]]
+[[Category: Saint-Andre C]]
+[[Category: Weixlbaumer A]]