1ysy: Difference between revisions

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[[Image:1ysy.gif|left|200px]]
{{Seed}}
[[Image:1ysy.png|left|200px]]


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{{STRUCTURE_1ysy|  PDB=1ysy  |  SCENE=  }}  
{{STRUCTURE_1ysy|  PDB=1ysy  |  SCENE=  }}  


'''NMR Structure of the nonstructural Protein 7 (nsP7) from the SARS CoronaVirus'''
===NMR Structure of the nonstructural Protein 7 (nsP7) from the SARS CoronaVirus===




==Overview==
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Here, we report the three-dimensional structure of severe acute respiratory syndrome coronavirus (SARS-CoV) nsP7, a component of the SARS-CoV replicase polyprotein. The coronavirus replicase carries out regulatory tasks involved in the maintenance, transcription, and replication of the coronavirus genome. nsP7 was found to assume a compact architecture in solution, which is comprised primarily of helical secondary structures. Three helices (alpha2 to alpha4) form a flat up-down-up antiparallel alpha-helix sheet. The N-terminal segment of residues 1 to 22, containing two turns of alpha-helix and one turn of 3(10)-helix, is packed across the surface of alpha2 and alpha3 in the helix sheet, with the alpha-helical region oriented at a 60 degrees angle relative to alpha2 and alpha3. The surface charge distribution is pronouncedly asymmetrical, with the flat surface of the helical sheet showing a large negatively charged region adjacent to a large hydrophobic patch and the opposite side containing a positively charged groove that extends along the helix alpha1. Each of these three areas is thus implicated as a potential site for protein-protein interactions.
The line below this paragraph, {{ABSTRACT_PUBMED_16188992}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16188992 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16188992}}


==About this Structure==
==About this Structure==
1YSY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSY OCA].  
1YSY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSY OCA].  


==Reference==
==Reference==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:44:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:18:41 2008''

Revision as of 05:18, 29 July 2008

File:1ysy.png

Template:STRUCTURE 1ysy

NMR Structure of the nonstructural Protein 7 (nsP7) from the SARS CoronaVirus

Template:ABSTRACT PUBMED 16188992

About this Structure

1YSY is a Single protein structure of sequence from Human sars coronavirus. Full experimental information is available from OCA.

Reference

Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7., Peti W, Johnson MA, Herrmann T, Neuman BW, Buchmeier MJ, Nelson M, Joseph J, Page R, Stevens RC, Kuhn P, Wuthrich K, J Virol. 2005 Oct;79(20):12905-13. PMID:16188992

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