1yt5: Difference between revisions

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[[Image:1yt5.gif|left|200px]]
{{Seed}}
[[Image:1yt5.png|left|200px]]


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{{STRUCTURE_1yt5|  PDB=1yt5  |  SCENE=  }}  
{{STRUCTURE_1yt5|  PDB=1yt5  |  SCENE=  }}  


'''Crystal structure of NAD kinase from Thermotoga maritima'''
===Crystal structure of NAD kinase from Thermotoga maritima===




==Overview==
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NAD kinase is the only known enzyme that catalyzes the formation of NADP, a coenzyme involved in most anabolic reactions and in the antioxidant defense system. Despite its importance, very little is known regarding the mechanism of catalysis and only recently have several NAD kinase structures been deposited in the PDB. Here, an independent investigation of the crystal structure of inorganic polyphosphate/ATP-NAD kinase, PPNK_THEMA, a protein from Thermotoga maritima, is reported at a resolution of 2.3 A. The crystal structure was solved using single-wavelength anomalous diffraction (SAD) data collected at the Se absorption-peak wavelength in a state in which no cofactors or substrates were bound. It revealed that the 258-amino-acid protein is folded into two distinct domains, similar to recently reported NAD kinases. The N-terminal alpha/beta-domain spans the first 100 amino acids and the last 30 amino acids of the polypeptide and has several topological matches in the PDB, whereas the other domain, which spans the middle 130 residues, adopts a unique beta-sandwich architecture and only appreciably matches the recently deposited PDB structures of NAD kinases.
The line below this paragraph, {{ABSTRACT_PUBMED_16511117}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16511117}}


==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:45:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:23:27 2008''

Revision as of 10:23, 28 July 2008

File:1yt5.png

Template:STRUCTURE 1yt5

Crystal structure of NAD kinase from Thermotoga maritima

Template:ABSTRACT PUBMED 16511117

About this Structure

1YT5 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structure of a NAD kinase from Thermotoga maritima at 2.3 A resolution., Oganesyan V, Huang C, Adams PD, Jancarik J, Yokota HA, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):640-6. Epub 2005 Jun 30. PMID:16511117

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