1yt9: Difference between revisions

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[[Image:1yt9.jpg|left|200px]]
{{Seed}}
[[Image:1yt9.png|left|200px]]


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{{STRUCTURE_1yt9|  PDB=1yt9  |  SCENE=  }}  
{{STRUCTURE_1yt9|  PDB=1yt9  |  SCENE=  }}  


'''HIV Protease with oximinoarylsulfonamide bound'''
===HIV Protease with oximinoarylsulfonamide bound===




==Overview==
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The need for a potent HIV protease inhibitor (PI) to combat emerging PI-resistant viruses is anticipated. Analogs formulated from the combination of structural fragments of Ritonavir, Lopinavir, and Amprenavir were synthesized. Analogs containing the oxime pharmacophore were found to have improved activities against both wild type and resistant (A17) viruses. The synthesis and structure-activity relationships (SAR) based upon the in vitro IC50 of this series of compounds are reported.
The line below this paragraph, {{ABSTRACT_PUBMED_15837308}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15837308 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837308}}


==About this Structure==
==About this Structure==
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[[Category: Hiv protease]]
[[Category: Hiv protease]]
[[Category: Oximinoarylsulfonamide]]
[[Category: Oximinoarylsulfonamide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:45:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:08:12 2008''