1ytv: Difference between revisions

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[[Image:1ytv.gif|left|200px]]
{{Seed}}
[[Image:1ytv.png|left|200px]]


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{{STRUCTURE_1ytv|  PDB=1ytv  |  SCENE=  }}  
{{STRUCTURE_1ytv|  PDB=1ytv  |  SCENE=  }}  


'''Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor'''
===Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor===




==Overview==
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The V1 vascular vasopressin receptor (V1R) is a G-protein-coupled receptor (GPCR) involved in the regulation of body-fluid osmolality, blood volume and blood pressure. Signal transduction is mediated by the third intracellular loop of this seven-transmembrane protein as well as by the C-terminal cytoplasmic segment. A chimera of the maltose-binding protein (MBP) and the C-terminal segment of V1R has been cloned, expressed, purified and crystallized. The crystals belong to space group P2(1), with unit-cell parameters a = 51.10, b = 66.56, c = 115.72 A, beta = 95.99 degrees. The 1.8 A crystal structure reveals the conformation of MBP and part of the linker region of this chimera, with the C-terminal segment being unstructured. This may reflect a conformational plasticity in the C-terminal segment that may be necessary for proper function of V1R.
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{{ABSTRACT_PUBMED_16511036}}


==About this Structure==
==About this Structure==
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[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Vasopressin]]
[[Category: Vasopressin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:47:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:04:07 2008''

Revision as of 10:04, 28 July 2008

File:1ytv.png

Template:STRUCTURE 1ytv

Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor

Template:ABSTRACT PUBMED 16511036

About this Structure

1YTV is a Protein complex structure of sequences from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA.

Reference

A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Adikesavan NV, Mahmood SS, Stanley N, Xu Z, Wu N, Thibonnier M, Shoham M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt, 4):341-5. Epub 2005 Mar 24. PMID:16511036

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