1yv1: Difference between revisions

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[[Image:1yv1.gif|left|200px]]
{{Seed}}
[[Image:1yv1.png|left|200px]]


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{{STRUCTURE_1yv1|  PDB=1yv1  |  SCENE=  }}  
{{STRUCTURE_1yv1|  PDB=1yv1  |  SCENE=  }}  


'''Fully reduced state of nigerythrin (all ferrous)'''
===Fully reduced state of nigerythrin (all ferrous)===




==Overview==
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High-resolution crystal structures of Desulfovibrio vulgaris nigerythrin (DvNgr), a member of the rubrerythrin (Rbr) family, demonstrate an approximately 2-A movement of one iron (Fe1) of the diiron site from a carboxylate to a histidine ligand upon conversion of the mixed-valent ([Fe2(II),Fe1(III)]) to diferrous states, even at cryogenic temperatures. This Glu&lt;--&gt;His ligand "toggling" of one iron, which also occurs in DvRbr, thus, appears to be a characteristic feature of Rbr-type diiron sites. Unique features of DvNgr revealed by these structures include redox-induced flipping of a peptide carbonyl that reversibly forms a hydrogen bond to the histidine ligand to Fe1 of the diiron site, an intra-subunit proximal orientation of the rubredoxin-(Rub)-like and diiron domains, and an electron transfer pathway consisting of six covalent and two hydrogen bonds connecting the Rub-like iron with Fe2 of the diiron site. This pathway can account for DvNgr's relatively rapid peroxidase turnover. The characteristic combination of iron sites together with the redox-dependent iron toggling between protein ligands can account for the selectivity of Rbrs for hydrogen peroxide over dioxygen.
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{{ABSTRACT_PUBMED_15895271}}


==About this Structure==
==About this Structure==
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[[Category: Rubredoxin]]
[[Category: Rubredoxin]]
[[Category: Rubrerythrin]]
[[Category: Rubrerythrin]]
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Revision as of 09:50, 29 July 2008

File:1yv1.png

Template:STRUCTURE 1yv1

Fully reduced state of nigerythrin (all ferrous)

Template:ABSTRACT PUBMED 15895271

About this Structure

1YV1 is a Single protein structure of sequence from Desulfovibrio vulgaris. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins., Iyer RB, Silaghi-Dumitrescu R, Kurtz DM Jr, Lanzilotta WN, J Biol Inorg Chem. 2005 Jun;10(4):407-16. Epub 2005 May 14. PMID:15895271

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