1yv3: Difference between revisions

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[[Image:1yv3.gif|left|200px]]
{{Seed}}
[[Image:1yv3.png|left|200px]]


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{{STRUCTURE_1yv3|  PDB=1yv3  |  SCENE=  }}  
{{STRUCTURE_1yv3|  PDB=1yv3  |  SCENE=  }}  


'''The structural basis of blebbistatin inhibition and specificity for myosin II'''
===The structural basis of blebbistatin inhibition and specificity for myosin II===




==Overview==
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Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.
The line below this paragraph, {{ABSTRACT_PUBMED_15750603}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15750603 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15750603}}


==About this Structure==
==About this Structure==
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[[Category: Myosin ii inhibitor]]
[[Category: Myosin ii inhibitor]]
[[Category: Myosin-inhibitor complex]]
[[Category: Myosin-inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:49:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:54:47 2008''
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