1yvf: Difference between revisions

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[[Image:1yvf.gif|left|200px]]
{{Seed}}
[[Image:1yvf.png|left|200px]]


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{{STRUCTURE_1yvf|  PDB=1yvf  |  SCENE=  }}  
{{STRUCTURE_1yvf|  PDB=1yvf  |  SCENE=  }}  


'''Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145'''
===Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145===




==Overview==
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A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.
The line below this paragraph, {{ABSTRACT_PUBMED_15863301}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15863301 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15863301}}


==About this Structure==
==About this Structure==
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[[Category: Polymerase]]
[[Category: Polymerase]]
[[Category: Thumb]]
[[Category: Thumb]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:50:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:42:07 2008''
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