9s15: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9s15 is ~~ON HOLD~~

==MspA-M2 in a POPC nanodisc==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9s15]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S15 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9S15 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=MHS:N1-METHYLATED+HISTIDINE'>MHS</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9s15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s15 OCA], [https://pdbe.org/9s15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s15 RCSB], [https://www.ebi.ac.uk/pdbsum/9s15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s15 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MSPA_MYCS2 MSPA_MYCS2] The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA channels into the membrane or by the existence of different MspA conformations.<ref>PMID:10476028</ref> <ref>PMID:16238622</ref> <ref>PMID:17209034</ref> <ref>PMID:18559650</ref> <ref>PMID:20952578</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mycolicibacterium smegmatis MC2 155]]

[[Category: Antson AA]]

[[Category: Ashworth M]]

[[Category: Bayfield OW]]

[[Category: Noble OW]]

[[Category: Plevin MJ]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9s15 is ON HOLD
+==MspA-M2 in a POPC nanodisc==
+<StructureSection load='9s15' size='340' side='right'caption='[[9s15]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9s15]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S15 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=MHS:N1-METHYLATED+HISTIDINE'>MHS</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s15 OCA], [https://pdbe.org/9s15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s15 RCSB], [https://www.ebi.ac.uk/pdbsum/9s15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s15 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MSPA_MYCS2 MSPA_MYCS2] The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA channels into the membrane or by the existence of different MspA conformations.<ref>PMID:10476028</ref> <ref>PMID:16238622</ref> <ref>PMID:17209034</ref> <ref>PMID:18559650</ref> <ref>PMID:20952578</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycolicibacterium smegmatis MC2 155]]
+[[Category: Antson AA]]
+[[Category: Ashworth M]]
+[[Category: Bayfield OW]]
+[[Category: Noble OW]]
+[[Category: Plevin MJ]]