1yx7: Difference between revisions

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[[Image:1yx7.gif|left|200px]]
{{Seed}}
[[Image:1yx7.png|left|200px]]


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{{STRUCTURE_1yx7|  PDB=1yx7  |  SCENE=  }}  
{{STRUCTURE_1yx7|  PDB=1yx7  |  SCENE=  }}  


'''NMR structure of Calsensin, energy minimized average structure.'''
===NMR structure of Calsensin, energy minimized average structure.===




==Overview==
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Calsensin is an EF-hand calcium-binding protein expressed by a subset of peripheral sensory neurons that fasciculate into a single tract in the leech central nervous system. Calsensin is a 9-kD protein with two EF-hand calcium-binding motifs. Using multidimensional NMR spectroscopy we have determined the solution structure and backbone dynamics of calcium-bound Calsensin. Calsensin consists of four helices forming a unicornate-type four-helix bundle. The residues in the third helix undergo slow conformational exchange indicating that the motion of this helix is associated with calciumbinding. The backbone dynamics of the protein as measured by (15)N relaxation rates and heteronuclear NOEs correlate well with the three-dimensional structure. Furthermore, comparison of the structure of Calsensin with other members of the EF-hand calcium-binding protein family provides insight into plausible mechanisms of calcium and target protein binding.
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{{ABSTRACT_PUBMED_15937283}}


==About this Structure==
==About this Structure==
1YX7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemopis_marmorata Haemopis marmorata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX7 OCA].  
1YX7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemopis_marmorata Haemopis marmorata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX7 OCA].  


==Reference==
==Reference==
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[[Category: Helix-loop-helix]]
[[Category: Helix-loop-helix]]
[[Category: Nervous system]]
[[Category: Nervous system]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:54:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:37:34 2008''

Revision as of 09:37, 28 July 2008

File:1yx7.png

Template:STRUCTURE 1yx7

NMR structure of Calsensin, energy minimized average structure.

Template:ABSTRACT PUBMED 15937283

About this Structure

1YX7 is a Single protein structure of sequence from Haemopis marmorata. Full experimental information is available from OCA.

Reference

Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein., Venkitaramani DV, Fulton DB, Andreotti AH, Johansen KM, Johansen J, Protein Sci. 2005 Jul;14(7):1894-901. Epub 2005 Jun 3. PMID:15937283

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