1yxk: Difference between revisions

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[[Image:1yxk.gif|left|200px]]
{{Seed}}
[[Image:1yxk.png|left|200px]]


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{{STRUCTURE_1yxk|  PDB=1yxk  |  SCENE=  }}  
{{STRUCTURE_1yxk|  PDB=1yxk  |  SCENE=  }}  


'''Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) disulfide-linked dimer'''
===Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) disulfide-linked dimer===




==Overview==
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Lectin-like, oxidized low-density lipoprotein (LDL) receptor 1, LOX-1, is the major receptor for oxidized LDL (OxLDL) in endothelial cells. We have determined the crystal structure of the ligand binding domain of LOX-1, with a short stalk region connecting the domain to the membrane-spanning region, as a homodimer linked by an interchain disulfide bond. In vivo assays with LOX-1 mutants revealed that the "basic spine," consisting of linearly aligned arginine residues spanning over the dimer surface, is responsible for ligand binding. Single amino acid substitution in the dimer interface caused a severe reduction in LOX-1 binding activity, suggesting that the correct dimer arrangement is crucial for binding to OxLDL. Based on the LDL model structure, possible binding modes of LOX-1 to OxLDL are proposed.
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{{ABSTRACT_PUBMED_15939022}}


==About this Structure==
==About this Structure==
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[[Category: Oxidized ldl receptor]]
[[Category: Oxidized ldl receptor]]
[[Category: Scavenger receptor]]
[[Category: Scavenger receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:55:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:23:29 2008''

Revision as of 10:23, 27 July 2008

File:1yxk.png

Template:STRUCTURE 1yxk

Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) disulfide-linked dimer

Template:ABSTRACT PUBMED 15939022

About this Structure

1YXK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL., Ohki I, Ishigaki T, Oyama T, Matsunaga S, Xie Q, Ohnishi-Kameyama M, Murata T, Tsuchiya D, Machida S, Morikawa K, Tate S, Structure. 2005 Jun;13(6):905-17. PMID:15939022

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