1yy3: Difference between revisions

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[[Image:1yy3.~~gif~~|left|200px]]

[[Image:1yy3.png|left|200px]]

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~~'''~~Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)~~'''~~

===Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)===

~~==Overview==~~

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The ~~enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) is involved in~~ the ~~biosynthesis of~~ the ~~hypermodified tRNA nucleoside queuosine. It is unprecedented in nature~~ as it ~~uses the cofactor S-adenosylmethionine as the donor of a ribosyl group. We have determined the crystal structure of Bacillus subtilis QueA~~ at ~~a resolution of 2~~.9A. ~~The structure reveals two domains representing a 6-stranded beta-barrel and an alpha beta alpha-sandwich~~, ~~respectively. All amino acid residues invariant in~~ the QueA enzymes of known sequence cluster at the interface of the two domains indicating the localization of the substrate binding region and active center. Comparison of the B. subtilis QueA structure with the structure of QueA from Thermotoga maritima suggests a high domain flexibility of this enzyme.

The line below this paragraph, {{ABSTRACT_PUBMED_17083917}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17083917 is the PubMed ID number.

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==About this Structure==

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[[Category: S-adenosylmethionine:trna ribosyltransferase-isomerase]]

[[Category: Trna-modification]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 16~~:56:52 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:58:47 2008''

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-[[Image:1yy3.gif|left|200px]]
+{{Seed}}
+[[Image:1yy3.png|left|200px]]
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 {{STRUCTURE_1yy3|  PDB=1yy3  |  SCENE=  }}
-'''Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)'''
+===Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)===
-==Overview==
+<!--
-The enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) is involved in the biosynthesis of the hypermodified tRNA nucleoside queuosine. It is unprecedented in nature as it uses the cofactor S-adenosylmethionine as the donor of a ribosyl group. We have determined the crystal structure of Bacillus subtilis QueA at a resolution of 2.9A. The structure reveals two domains representing a 6-stranded beta-barrel and an alpha beta alpha-sandwich, respectively. All amino acid residues invariant in the QueA enzymes of known sequence cluster at the interface of the two domains indicating the localization of the substrate binding region and active center. Comparison of the B. subtilis QueA structure with the structure of QueA from Thermotoga maritima suggests a high domain flexibility of this enzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_17083917}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17083917 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17083917}}
 ==About this Structure==
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 [[Category: S-adenosylmethionine:trna ribosyltransferase-isomerase]]
 [[Category: Trna-modification]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:56:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:58:47 2008''