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| [[Image:1yyb.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1yyb| PDB=1yyb | SCENE= }} | | {{STRUCTURE_1yyb| PDB=1yyb | SCENE= }} |
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| '''Solution structure of 1-26 fragment of human programmed cell death 5 protein'''
| | ===Solution structure of 1-26 fragment of human programmed cell death 5 protein=== |
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| ==Overview==
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| PDCD5-(1-26) is a N-terminal 26-residue fragment of human PDCD5 (programmed cell death 5) protein. PDCD5 is an important novel protein that regulates both apoptotic and non-apoptotic programmed cell death. The conformation of PDCD5 protein is a stable helical core consisting of a triple-helix bundle and two dissociated terminal regions. The N-terminal region is ordered and contains abundant secondary structure. Overexpression and purification of the N-terminal 26-residure fragment, PDCD5-(1-26), was performed in this study to better understand its tertiary structure. The spectroscopic studies using CD and hetero- and homo-nuclear NMR methods determine a stable alpha-helix formed by Asp3-Ala19 of PDCD5-(1-26). The N-terminal residues Asp3-Ala19 of PDCD5 were then affirmed to have the capacity to form a stable alpha-helix independently of the core of the protein. Analysis of the helical peptide of PDCD5-(1-26) indicates that the surface of this well-formed alpha-helix has a unique electrostatic potential character. This may provide an environment for the N-terminal alpha-helix of PDCD5 to serve as an independent functional entity of the protein. The apoptosis activity assay shows that the deletion of the N-terminal alpha-helix of PDCD5 significantly attenuates the apoptosis-promoting effects on HL-60 cells induced by serum withdrawal.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16083422}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16083422 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16083422}} |
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| ==About this Structure== | | ==About this Structure== |
| 1YYB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYB OCA]. | | 1YYB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYB OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Yao, H W.]] | | [[Category: Yao, H W.]] |
| [[Category: Solution structure]] | | [[Category: Solution structure]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:57:24 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:47:40 2008'' |
