1yyh: Difference between revisions

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[[Image:1yyh.gif|left|200px]]
{{Seed}}
[[Image:1yyh.png|left|200px]]


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{{STRUCTURE_1yyh|  PDB=1yyh  |  SCENE=  }}  
{{STRUCTURE_1yyh|  PDB=1yyh  |  SCENE=  }}  


'''Crystal structure of the human Notch 1 ankyrin domain'''
===Crystal structure of the human Notch 1 ankyrin domain===




==Overview==
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The Notch receptor is part of a highly conserved signalling system of central importance to animal development. Its ANK (ankyrin) domain is required for Notch-mediated signal transduction. The crystal structure of the human Notch 1 ANK domain was solved by molecular replacement at 1.9 A (1 A=0.1 nm) resolution, and it shows that the features identified in the Drosophila homologue are conserved. The domain has six of the seven ANK repeats predicted from sequence. The putative first repeat, which has only part of the consensus and a long insertion, is disordered in both molecules in the asymmetric unit, possibly due to the absence of the RAM (RBPJkappa-associated molecule) region N-terminal to it. The exposed hydrophobic core is involved in intermolecular interactions in the crystal. Evolutionary trace analysis identified several residues that map to the hairpins of the structure and may be of functional importance. Based on the Notch 1 ANK structure and analysis of homologous Notch ANK sequences, we predict two possible binding sites on the domain: one on the concave surface of repeat 2 and the other below the hairpins of repeats 6-7.
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{{ABSTRACT_PUBMED_16011479}}


==About this Structure==
==About this Structure==
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[[Category: Ankyrin repeat]]
[[Category: Ankyrin repeat]]
[[Category: Notch 1]]
[[Category: Notch 1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:57:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:44:06 2008''

Revision as of 05:44, 28 July 2008

File:1yyh.png

Template:STRUCTURE 1yyh

Crystal structure of the human Notch 1 ankyrin domain

Template:ABSTRACT PUBMED 16011479

About this Structure

1YYH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structure of the human Notch 1 ankyrin domain., Ehebauer MT, Chirgadze DY, Hayward P, Martinez Arias A, Blundell TL, Biochem J. 2005 Nov 15;392(Pt 1):13-20. PMID:16011479

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