1yyn: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1yyn.gif|left|200px]]
{{Seed}}
[[Image:1yyn.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1yyn|  PDB=1yyn  |  SCENE=  }}  
{{STRUCTURE_1yyn|  PDB=1yyn  |  SCENE=  }}  


'''A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin'''
===A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin===




==Overview==
<!--  
Clostridial neurotoxins are comprised of botulinum (BoNT) and tetanus (TeNT), which share significant structural and functional similarity. Crystal structures of the binding domain of TeNT complexed with disialyllactose (DiSia) and a tri-peptide Tyr-Glu-Trp (YEW) have been determined to 2.3 and 2.2 A, respectively. Both DiSia and YEW bind in a shallow cleft region on the surface of the molecule in the beta-trefoil domain, interacting with a set of common residues, Asp1147, Asp1214, Asn1216, and Arg1226. DiSia and YEW binding at the same site in tetanus toxin provides a putative site that could be occupied either by a ganglioside moiety or a peptide. Soaking experiments with a mixture of YEW and DiSia show that YEW competes with DiSia, suggesting that YEW can be used to block ganglioside binding. A comparison with the TeNT binding domain in complex with small molecules, BoNT/A and /B, provides insight into the different modes of ganglioside binding.
The line below this paragraph, {{ABSTRACT_PUBMED_16104015}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16104015 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16104015}}


==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Tetanus toxin]]
[[Category: Tetanus toxin]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:58:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:50:12 2008''

Revision as of 15:50, 27 July 2008

File:1yyn.png

Template:STRUCTURE 1yyn

A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin

Template:ABSTRACT PUBMED 16104015

About this Structure

1YYN is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

Reference

Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin., Jayaraman S, Eswaramoorthy S, Kumaran D, Swaminathan S, Proteins. 2005 Nov 1;61(2):288-95. PMID:16104015

Page seeded by OCA on Sun Jul 27 18:50:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1yyn&oldid=661576"