1z3f: Difference between revisions

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[[Image:1z3f.gif|left|200px]]
{{Seed}}
[[Image:1z3f.png|left|200px]]


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{{STRUCTURE_1z3f|  PDB=1z3f  |  SCENE=  }}  
{{STRUCTURE_1z3f|  PDB=1z3f  |  SCENE=  }}  


'''Structure of ellipticine in complex with a 6-bp DNA'''
===Structure of ellipticine in complex with a 6-bp DNA===




==Overview==
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Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.
The line below this paragraph, {{ABSTRACT_PUBMED_15983425}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15983425 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15983425}}


==About this Structure==
==About this Structure==
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[[Category: Ellipticine]]
[[Category: Ellipticine]]
[[Category: Intercalator]]
[[Category: Intercalator]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:08:07 2008''
 
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