1z4n: Difference between revisions

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[[Image:1z4n.~~gif~~|left|200px]]

[[Image:1z4n.png|left|200px]]

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~~'''~~Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride~~'''~~

===Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride===

~~==Overview==~~

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~~This communication reports the X~~-~~ray crystal structure of the alpha~~-d-galactose-1-phosphate complex with that of Lactococcus lactis beta-phosphoglucomutase (beta-PGM) crystallized in the presence of Mg2+ cofactor and the enzyme-to-phosphorus ratio determined by protein and phosphate analyses of the crystalline complex. The ~~1:1 ratio determined for~~ this ~~complex was compared~~ to the 1:~~2 ratio determined for the crystals of beta-PGM grown in the presence of substrate and Mg2+ cofactor~~. ~~This result verifies the published structure assignment of this latter complex as the phosphorane adduct formed by covalent bonding between the active site Asp8 carboxylate to the C(1~~)~~phosphorus of the beta-glucose 1~~,~~6-bisphosphate ligand and rules out~~ the ~~proposal of a beta~~-~~PGM~~-~~glucose-6-phosphate-1-MgF3- complex.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15826149}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15826149 is the PubMed ID number.

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==About this Structure==

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[[Category: Beta-phosphoglucomutase]]

[[Category: Isomerase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:10:21 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:29:46 2008''

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-[[Image:1z4n.gif|left|200px]]
+{{Seed}}
+[[Image:1z4n.png|left|200px]]
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 {{STRUCTURE_1z4n|  PDB=1z4n  |  SCENE=  }}
-'''Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride'''
+===Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride===
-==Overview==
+<!--
-This communication reports the X-ray crystal structure of the alpha-d-galactose-1-phosphate complex with that of Lactococcus lactis beta-phosphoglucomutase (beta-PGM) crystallized in the presence of Mg2+ cofactor and the enzyme-to-phosphorus ratio determined by protein and phosphate analyses of the crystalline complex. The 1:1 ratio determined for this complex was compared to the 1:2 ratio determined for the crystals of beta-PGM grown in the presence of substrate and Mg2+ cofactor. This result verifies the published structure assignment of this latter complex as the phosphorane adduct formed by covalent bonding between the active site Asp8 carboxylate to the C(1)phosphorus of the beta-glucose 1,6-bisphosphate ligand and rules out the proposal of a beta-PGM-glucose-6-phosphate-1-MgF3- complex.
+The line below this paragraph, {{ABSTRACT_PUBMED_15826149}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15826149 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15826149}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Beta-phosphoglucomutase]]
 [[Category: Isomerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:10:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:29:46 2008''