1z7s: Difference between revisions

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[[Image:1z7s.gif|left|200px]]
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[[Image:1z7s.png|left|200px]]


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{{STRUCTURE_1z7s|  PDB=1z7s  |  SCENE=  }}  
{{STRUCTURE_1z7s|  PDB=1z7s  |  SCENE=  }}  


'''The crystal structure of coxsackievirus A21'''
===The crystal structure of coxsackievirus A21===




==Overview==
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CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.
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{{ABSTRACT_PUBMED_16004874}}


==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Picornavirus,coxsackievirus,a21,capsid protein,viral protein]]
[[Category: Picornavirus,coxsackievirus,a21,capsid protein,viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:17:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:59:38 2008''

Revision as of 09:59, 27 July 2008

File:1z7s.png

Template:STRUCTURE 1z7s

The crystal structure of coxsackievirus A21

Template:ABSTRACT PUBMED 16004874

About this Structure

1Z7S is a Protein complex structure of sequences from Human coxsackievirus a21. Full crystallographic information is available from OCA.

Reference

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874

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