1z92: Difference between revisions

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[[Image:1z92.gif|left|200px]]
{{Seed}}
[[Image:1z92.png|left|200px]]


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{{STRUCTURE_1z92|  PDB=1z92  |  SCENE=  }}  
{{STRUCTURE_1z92|  PDB=1z92  |  SCENE=  }}  


'''structure of interleukin-2 with its alpha receptor'''
===structure of interleukin-2 with its alpha receptor===




==Overview==
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Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.
The line below this paragraph, {{ABSTRACT_PUBMED_15933202}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15933202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15933202}}


==Disease==
==Disease==
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[[Category: Interleukin-2]]
[[Category: Interleukin-2]]
[[Category: Interleukin-2 alpha receptor]]
[[Category: Interleukin-2 alpha receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:19:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:16:39 2008''
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