1z9b: Difference between revisions

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[[Image:1z9b.gif|left|200px]]
{{Seed}}
[[Image:1z9b.png|left|200px]]


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{{STRUCTURE_1z9b|  PDB=1z9b  |  SCENE=  }}  
{{STRUCTURE_1z9b|  PDB=1z9b  |  SCENE=  }}  


'''Solution structure of the C1-subdomain of Bacillus stearothermophilus translation initiation factor IF2'''
===Solution structure of the C1-subdomain of Bacillus stearothermophilus translation initiation factor IF2===




==Overview==
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IF2 is one of three bacterial translation initiation factors that are conserved through all kingdoms of life. It binds the 30S and 50S ribosomal subunits, as well as fMet-tRNAf(Met). After these interactions, fMet-tRNAf(Met) is oriented to the ribosomal P-site where the first amino acid of the nascent polypeptide, formylmethionine, is presented. The C-terminal domain of Bacillus stearothermophilus IF2, which is responsible for recognition and binding of fMet-tRNAf(Met), contains two structured modules. Previously, the solution structure of the most C-terminal module, IF2-C2, has been elucidated by NMR spectroscopy and direct interactions between this subdomain and fMet-tRNAf(Met) were reported. In the present NMR study we have obtained the spectral assignment of the other module of the C-terminal domain (IF2-C1) and determined its solution structure and backbone dynamics. The IF2-C1 core forms a flattened fold consisting of a central four-stranded parallel beta-sheet flanked by three alpha-helices. Although its overall organization resembles that of subdomain III of the archaeal IF2-homolog eIF5B whose crystal structure had previously been reported, some differences of potential functional significance are evident.
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{{ABSTRACT_PUBMED_16081655}}


==About this Structure==
==About this Structure==
1Z9B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9B OCA].  
1Z9B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9B OCA].  


==Reference==
==Reference==
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[[Category: Wienk, H.]]
[[Category: Wienk, H.]]
[[Category: Protein synthesis translation intiation if2 fmet-trna nmr structure]]
[[Category: Protein synthesis translation intiation if2 fmet-trna nmr structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:20:32 2008''
 
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Revision as of 03:10, 28 July 2008

File:1z9b.png

Template:STRUCTURE 1z9b

Solution structure of the C1-subdomain of Bacillus stearothermophilus translation initiation factor IF2

Template:ABSTRACT PUBMED 16081655

About this Structure

1Z9B is a Single protein structure of sequence from Geobacillus stearothermophilus. Full experimental information is available from OCA.

Reference

Solution structure of the C1-subdomain of Bacillus stearothermophilus translation initiation factor IF2., Wienk H, Tomaselli S, Bernard C, Spurio R, Picone D, Gualerzi CO, Boelens R, Protein Sci. 2005 Sep;14(9):2461-8. Epub 2005 Aug 4. PMID:16081655

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