1z9e: Difference between revisions

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[[Image:1z9e.gif|left|200px]]
{{Seed}}
[[Image:1z9e.png|left|200px]]


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{{STRUCTURE_1z9e|  PDB=1z9e  |  SCENE=  }}  
{{STRUCTURE_1z9e|  PDB=1z9e  |  SCENE=  }}  


'''Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75'''
===Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75===




==Overview==
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Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase (IN) in human cells. We have determined the NMR structure of the integrase-binding domain (IBD) in LEDGF and identified amino acid residues essential for the interaction. The IBD is a compact right-handed bundle composed of five alpha-helices. Based on folding topology, the IBD is structurally related to a diverse family of alpha-helical proteins that includes eukaryotic translation initiation factor eIF4G and karyopherin-beta. LEDGF residues essential for the interaction with IN were localized to interhelical loop regions of the bundle structure. Interaction-defective IN mutants were previously shown to cripple replication although they retained catalytic function. The initial structure determination of a host cell factor that tightly binds to a retroviral enzyme lays the groundwork for understanding enzyme-host interactions important for viral replication.
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(as it appears on PubMed at http://www.pubmed.gov), where 15895093 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15895093}}


==About this Structure==
==About this Structure==
1Z9E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9E OCA].  
1Z9E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9E OCA].  


==Reference==
==Reference==
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[[Category: Heat repeat-like]]
[[Category: Heat repeat-like]]
[[Category: Ledgf]]
[[Category: Ledgf]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:20:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:24:17 2008''
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