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| {{STRUCTURE_1zbe| PDB=1zbe | SCENE= }} | | {{STRUCTURE_1zbe| PDB=1zbe | SCENE= }} |
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| '''Foot-and Mouth Disease Virus Serotype A1061'''
| | ===Foot-and Mouth Disease Virus Serotype A1061=== |
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| ==Overview==
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| Foot-and-mouth disease viruses (FMDVs) target epithelial cells via integrin receptors, but can acquire the capacity to bind cell-surface heparan sulphate (or alternative receptors) on passage in cell culture. Vaccine viruses must be propagated in cell culture and, hence, some rationale for the selection of variants in this process is important. Crystal structures are available for type O, A and C viruses and also for a complex of type O strain O(1)BFS with heparin. The structure of FMDV A10(61) (a cell culture-adapted strain) complexed with heparin has now been determined. This virus has an RGSD motif in place of the otherwise conserved RGD integrin-binding motif and the potential to bind heparan sulphate (suggested by sequence analyses). FMDV A10(61) was closely similar in structure to other serotypes, deviating most in antigenic sites. The VP1 GH loop comprising the integrin-binding motif was disordered. Heparin bound at a similar site and in a similar conformation to that seen in the analogous complex with O(1)BFS, although the binding had a lower affinity and was more ionic.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15958669}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15958669 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15958669}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Icosahedral virus]] | | [[Category: Icosahedral virus]] |
| [[Category: Virus/viral protein]] | | [[Category: Virus/viral protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:25:04 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:34:28 2008'' |
