1zea: Difference between revisions

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[[Image:1zea.gif|left|200px]]
{{Seed}}
[[Image:1zea.png|left|200px]]


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{{STRUCTURE_1zea|  PDB=1zea  |  SCENE=  }}  
{{STRUCTURE_1zea|  PDB=1zea  |  SCENE=  }}  


'''Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide'''
===Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide===




==Overview==
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The structure of a complex of the anti-cholera toxin antibody TE33 Fab (fragment antibody) with the D-peptide vpGsqhyds was solved to 1.78 A resolution. The D-peptide was derived from the linear L-peptide epitope VPGSQHIDS by a stepwise transformation. Despite the very similar amino acid sequence-the only difference is a tyrosine residue in position 7-there are marked differences in the individual positions with respect to their contribution to the peptide overall affinity as ascertained by a complete substitutional analysis. This is reflected by the X-ray structure of the TE33 Fab/D-peptide complex where there is an inverted orientation of the D-peptide as compared with the known structure of a corresponding complex containing the epitope L-peptide, with the side chains establishing different contacts within the binding site of TE33. The D- and L-peptide affinities are comparable and the surface areas buried by complex formation are almost the same. Thus the antibody TE33 provides a typical example for polyspecific binding behavior of IgG family antibodies.
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{{ABSTRACT_PUBMED_17712773}}


==About this Structure==
==About this Structure==
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[[Category: Polyspecificity]]
[[Category: Polyspecificity]]
[[Category: Substitution matrix]]
[[Category: Substitution matrix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:31:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:29:25 2008''

Revision as of 23:29, 28 July 2008

File:1zea.png

Template:STRUCTURE 1zea

Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide

Template:ABSTRACT PUBMED 17712773

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:17712773

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