1zgr: Difference between revisions

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[[Image:1zgr.gif|left|200px]]
{{Seed}}
[[Image:1zgr.png|left|200px]]


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{{STRUCTURE_1zgr|  PDB=1zgr  |  SCENE=  }}  
{{STRUCTURE_1zgr|  PDB=1zgr  |  SCENE=  }}  


'''Crystal structure of the Parkia platycephala seed lectin'''
===Crystal structure of the Parkia platycephala seed lectin===




==Overview==
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The crystal structures of the apo and mannose-bound Parkia platycephala seed lectin represent the first structure of a Mimosoideae lectin and a novel circular arrangement of beta-prism domains, and highlight the adaptability of the beta-prism fold as a building block in the evolution of plant lectins. The P.platycephala lectin is a dimer both in solution and in the crystals. Mannose binding to each of the three homologous carbohydrate-recognition domains of the lectin occurs through different modes, and restrains the flexibility of surface-exposed loops and residues involved in carbohydrate recognition. The planar array of carbohydrate-binding sites on the rim of the toroid-shaped structure of the P.platycephala lectin dimer immediately suggests a mechanism to promote multivalent interactions leading to cross-linking of carbohydrate ligands as part of the host strategy against phytopredators and pathogens. The cyclic structure of the P.platycephala lectin points to the convergent evolution of a structural principle for the construction of lectins involved in host defense or in attacking other organisms.
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{{ABSTRACT_PUBMED_16185708}}


==About this Structure==
==About this Structure==
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[[Category: Beta-prism]]
[[Category: Beta-prism]]
[[Category: Lectin]]
[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:11:40 2008''

Revision as of 14:11, 27 July 2008

File:1zgr.png

Template:STRUCTURE 1zgr

Crystal structure of the Parkia platycephala seed lectin

Template:ABSTRACT PUBMED 16185708

About this Structure

1ZGR is a Single protein structure of sequence from Parkia platycephala. Full crystallographic information is available from OCA.

Reference

The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain., Gallego del Sol F, Nagano C, Cavada BS, Calvete JJ, J Mol Biol. 2005 Oct 28;353(3):574-83. Epub 2005 Sep 9. PMID:16185708

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