1zk9: Difference between revisions

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[[Image:1zk9.gif|left|200px]]
{{Seed}}
[[Image:1zk9.png|left|200px]]


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{{STRUCTURE_1zk9|  PDB=1zk9  |  SCENE=  }}  
{{STRUCTURE_1zk9|  PDB=1zk9  |  SCENE=  }}  


'''NF-kB RelB forms an intertwined homodimer'''
===NF-kB RelB forms an intertwined homodimer===




==Overview==
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The X-ray structure of the RelB dimerization domain (DD) reveals that the RelBDD assumes an unexpected intertwined fold topology atypical of other NF-kappaB dimers. All typical NF-kappaB dimers are formed by the association of two independently folded immunoglobulin (Ig) domains. In RelBDD, two polypeptides reconstruct both Ig domains in the dimer with an extra beta sheet connecting the two domains. Residues most critical to NF-kappaB dimer formation are invariant in RelB, and Y300 plays a positive role in RelBDD dimer formation. The presence of RelB-specific nonpolar residues at the surface removes several intradomain surface hydrogen bonds that may render the domain fold unstable. Intertwining may stabilize the RelBDD homodimer by forming the extra beta sheet. We show that, as in the crystal, RelB forms an intertwined homodimer in solution. We suggest that the transiently stable RelB homodimer might prevent its rapid degradation, allowing for heterodimer formation with p50 and p52.
The line below this paragraph, {{ABSTRACT_PUBMED_16154093}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16154093 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16154093}}


==About this Structure==
==About this Structure==
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[[Category: Nf-kb]]
[[Category: Nf-kb]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:43:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:02:00 2008''

Revision as of 06:02, 29 July 2008

File:1zk9.png

Template:STRUCTURE 1zk9

NF-kB RelB forms an intertwined homodimer

Template:ABSTRACT PUBMED 16154093

About this Structure

1ZK9 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

NF-kappaB RelB forms an intertwined homodimer., Huang DB, Vu D, Ghosh G, Structure. 2005 Sep;13(9):1365-73. PMID:16154093

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