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| {{STRUCTURE_1zld| PDB=1zld | SCENE= }} | | {{STRUCTURE_1zld| PDB=1zld | SCENE= }} |
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| '''Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA'''
| | ===Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA=== |
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| ==Overview==
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| Tan spot of wheat (Triticum aestivum), caused by the fungus Pyrenophora tritici-repentis, has significant agricultural and economic impact. Ptr ToxA (ToxA), the first discovered proteinaceous host-selective toxin, is produced by certain P. tritici-repentis races and is necessary and sufficient to cause cell death in sensitive wheat cultivars. We present here the high-resolution crystal structure of ToxA in two different crystal forms, providing four independent views of the protein. ToxA adopts a single-domain, beta-sandwich fold of novel topology. Mapping of the existing mutation data onto the structure supports the hypothesized importance of an Arg-Gly-Asp (RGD) and surrounding sequence. Its occurrence in a single, solvent-exposed loop in the protein suggests that it is directly involved in recognition events required for ToxA action. Furthermore, the ToxA structure reveals a surprising similarity with the classic mammalian RGD-containing domain, the fibronectin type III (FnIII) domain: the two topologies are related by circular permutation. The similar topologies and the positional conservation of the RGD-containing loop raises the possibility that ToxA is distantly related to mammalian FnIII proteins and that to gain entry it binds to an integrin-like receptor in the plant host.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16214901}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16214901 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16214901}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Beta-sandwich]] | | [[Category: Beta-sandwich]] |
| [[Category: Rgd-motif]] | | [[Category: Rgd-motif]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:46:05 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:19:43 2008'' |
