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[[Image:1zu1.gif|left|200px]]
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[[Image:1zu1.png|left|200px]]


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{{STRUCTURE_1zu1|  PDB=1zu1  |  SCENE=  }}  
{{STRUCTURE_1zu1|  PDB=1zu1  |  SCENE=  }}  


'''Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa'''
===Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa===




==Overview==
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Several zinc finger proteins have been discovered recently that bind specifically to double-stranded RNA. These include the mammalian JAZ and wig proteins, and the seven-zinc finger protein ZFa from Xenopus laevis. We have determined the solution structure of a 127 residue fragment of ZFa, which consists of two zinc finger domains connected by a linker that remains unstructured in the free protein in solution. The first zinc finger consists of a three-stranded beta-sheet and three helices, while the second finger contains only a two-stranded sheet and two helices. The common structures of the core regions of the two fingers are superimposable. Each finger has a highly electropositive surface that maps to a helix-kink-helix motif. There is no evidence for interactions between the two fingers, consistent with the length (24 residues) and unstructured nature of the intervening linker. Comparison with a number of other proteins shows similarities in the topology and arrangement of secondary structure elements with canonical DNA-binding zinc fingers, with protein interaction motifs such as FOG zinc fingers, and with other DNA-binding and RNA-binding proteins that do not contain zinc. However, in none of these cases does the alignment of these structures with the ZFa zinc fingers produce a consistent picture of a plausible RNA-binding interface. We conclude that the ZFa zinc fingers represent a new motif for the binding of double-stranded RNA.
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{{ABSTRACT_PUBMED_16051273}}


==About this Structure==
==About this Structure==
1ZU1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU1 OCA].  
1ZU1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU1 OCA].  


==Reference==
==Reference==
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[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
[[Category: Zinc finger protein]]
[[Category: Zinc finger protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:04:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:02:45 2008''

Revision as of 16:02, 27 July 2008

File:1zu1.png

Template:STRUCTURE 1zu1

Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa

Template:ABSTRACT PUBMED 16051273

About this Structure

1ZU1 is a Single protein structure of sequence from Xenopus laevis. Full experimental information is available from OCA.

Reference

Solution structure of the N-terminal zinc fingers of the Xenopus laevis double-stranded RNA-binding protein ZFa., Moller HM, Martinez-Yamout MA, Dyson HJ, Wright PE, J Mol Biol. 2005 Aug 26;351(4):718-30. PMID:16051273

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