1zwl: Difference between revisions

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~~'''~~Structure of WrbA from Pseudomonas aeruginosa in complex with FMN~~'''~~

===Structure of WrbA from Pseudomonas aeruginosa in complex with FMN===

~~==Overview==~~

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The ~~tryptophan repressor binding protein WrbA binds to the tryptophan repressor protein TrpR. Although~~ the ~~biological role of WrbA remains unclear, it has been proposed~~ to ~~function in enhancing~~ the ~~stability of TrpR-DNA complexes. Sequence database analysis has identified WrbA~~ as ~~a founding member of a flavodoxin-like family of proteins~~. ~~Here we present crystal structures of WrbA from Deinococcus radiodurans and Pseudomonas aeruginosa and their complexes with flavin mononucleotide~~. ~~The protomer structure~~ is ~~similar to that of previously determined long-chain flavodoxins; however, each contains a conserved inserted region unique to~~ the ~~WrbA family~~. ~~Interestingly, each WrbA protein forms a homotetramer with 222 symmetry, unique among flavodoxin~~-~~like proteins, in which each protomer binds one flavin mononucleotide cofactor molecule.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16322580}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16322580 is the PubMed ID number.

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==About this Structure==

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[[Category: Structural genomic]]

[[Category: Wrba]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:09:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:40:12 2008''

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-[[Image:1zwl.gif|left|200px]]
+{{Seed}}
+[[Image:1zwl.png|left|200px]]
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 {{STRUCTURE_1zwl|  PDB=1zwl  |  SCENE=  }}
-'''Structure of WrbA from Pseudomonas aeruginosa in complex with FMN'''
+===Structure of WrbA from Pseudomonas aeruginosa in complex with FMN===
-==Overview==
+<!--
-The tryptophan repressor binding protein WrbA binds to the tryptophan repressor protein TrpR. Although the biological role of WrbA remains unclear, it has been proposed to function in enhancing the stability of TrpR-DNA complexes. Sequence database analysis has identified WrbA as a founding member of a flavodoxin-like family of proteins. Here we present crystal structures of WrbA from Deinococcus radiodurans and Pseudomonas aeruginosa and their complexes with flavin mononucleotide. The protomer structure is similar to that of previously determined long-chain flavodoxins; however, each contains a conserved inserted region unique to the WrbA family. Interestingly, each WrbA protein forms a homotetramer with 222 symmetry, unique among flavodoxin-like proteins, in which each protomer binds one flavin mononucleotide cofactor molecule.
+The line below this paragraph, {{ABSTRACT_PUBMED_16322580}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16322580 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16322580}}
 ==About this Structure==
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 [[Category: Structural genomic]]
 [[Category: Wrba]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:09:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:40:12 2008''