1zy7: Difference between revisions

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[[Image:1zy7.~~gif~~|left|200px]]

[[Image:1zy7.png|left|200px]]

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~~'''~~Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (hADAR2) bound to inositol hexakisphosphate (IHP)~~'''~~

===Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (hADAR2) bound to inositol hexakisphosphate (IHP)===

~~==Overview==~~

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~~We report the crystal structure of the catalytic domain of human ADAR2~~, ~~an RNA editing enzyme~~, ~~at 1.7 angstrom resolution. The structure reveals a zinc ion in~~ the ~~active site and suggests how~~ the ~~substrate adenosine is recognized~~. ~~Unexpectedly, inositol hexakisphosphate (IP6) is buried within the enzyme core, contributing to the protein fold~~. ~~Although there are no reports that adenosine deaminases that act on RNA (ADARs~~) ~~require a cofactor~~, ~~we show that IP6~~ is ~~required for activity. Amino acids that coordinate IP6 in~~ the crystal structure are conserved in some adenosine deaminases that act on transfer RNA (tRNA) (ADATs), related enzymes that edit tRNA. Indeed, IP6 is also essential for in vivo and in vitro deamination of adenosine 37 of tRNAala by ADAT1.

The line below this paragraph, {{ABSTRACT_PUBMED_16141067}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16141067 is the PubMed ID number.

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==About this Structure==

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[[Category: Ionsitol hexakisphosphate]]

[[Category: Zinc coordination]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:13:35 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:32:52 2008''

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-[[Image:1zy7.gif|left|200px]]
+{{Seed}}
+[[Image:1zy7.png|left|200px]]
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 {{STRUCTURE_1zy7|  PDB=1zy7  |  SCENE=  }}
-'''Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (hADAR2) bound to inositol hexakisphosphate (IHP)'''
+===Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (hADAR2) bound to inositol hexakisphosphate (IHP)===
-==Overview==
+<!--
-We report the crystal structure of the catalytic domain of human ADAR2, an RNA editing enzyme, at 1.7 angstrom resolution. The structure reveals a zinc ion in the active site and suggests how the substrate adenosine is recognized. Unexpectedly, inositol hexakisphosphate (IP6) is buried within the enzyme core, contributing to the protein fold. Although there are no reports that adenosine deaminases that act on RNA (ADARs) require a cofactor, we show that IP6 is required for activity. Amino acids that coordinate IP6 in the crystal structure are conserved in some adenosine deaminases that act on transfer RNA (tRNA) (ADATs), related enzymes that edit tRNA. Indeed, IP6 is also essential for in vivo and in vitro deamination of adenosine 37 of tRNAala by ADAT1.
+The line below this paragraph, {{ABSTRACT_PUBMED_16141067}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16141067 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16141067}}
 ==About this Structure==
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 [[Category: Ionsitol hexakisphosphate]]
 [[Category: Zinc coordination]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:13:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:32:52 2008''