2a1t: Difference between revisions

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[[Image:2a1t.gif|left|200px]]
{{Seed}}
[[Image:2a1t.png|left|200px]]


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{{STRUCTURE_2a1t|  PDB=2a1t  |  SCENE=  }}  
{{STRUCTURE_2a1t|  PDB=2a1t  |  SCENE=  }}  


'''Structure of the human MCAD:ETF E165betaA complex'''
===Structure of the human MCAD:ETF E165betaA complex===




==Overview==
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Crystal structures of protein complexes with electron-transferring flavoprotein (ETF) have revealed a dual protein-protein interface with one region serving as anchor while the ETF FAD domain samples available space within the complex. We show that mutation of the conserved Glu-165beta in human ETF leads to drastically modulated rates of interprotein electron transfer with both medium chain acyl-CoA dehydrogenase and dimethylglycine dehydrogenase. The crystal structure of free E165betaA ETF is essentially identical to that of wild-type ETF, but the crystal structure of the E165betaA ETF.medium chain acyl-CoA dehydrogenase complex reveals clear electron density for the FAD domain in a position optimal for fast interprotein electron transfer. Based on our observations, we present a dynamic multistate model for conformational sampling that for the wild-type ETF. medium chain acyl-CoA dehydrogenase complex involves random motion between three distinct positions for the ETF FAD domain. ETF Glu-165beta plays a key role in stabilizing positions incompatible with fast interprotein electron transfer, thus ensuring high rates of complex dissociation.
The line below this paragraph, {{ABSTRACT_PUBMED_15975918}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15975918 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15975918}}


==About this Structure==
==About this Structure==
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[[Category: Fatty acid b-degradation]]
[[Category: Fatty acid b-degradation]]
[[Category: Protein:protein complex]]
[[Category: Protein:protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:29:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:00:09 2008''

Revision as of 03:00, 29 July 2008

File:2a1t.png

Template:STRUCTURE 2a1t

Structure of the human MCAD:ETF E165betaA complex

Template:ABSTRACT PUBMED 15975918

About this Structure

2A1T is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein., Toogood HS, van Thiel A, Scrutton NS, Leys D, J Biol Chem. 2005 Aug 26;280(34):30361-6. Epub 2005 Jun 23. PMID:15975918

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