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| [[Image:2a2b.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2a2b| PDB=2a2b | SCENE= }} | | {{STRUCTURE_2a2b| PDB=2a2b | SCENE= }} |
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| '''Curvacin A'''
| | ===Curvacin A=== |
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| ==Overview==
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| The 3D structure of the membrane-permeabilizing 41-mer pediocin-like antimicrobial peptide curvacin A produced by lactic acid bacteria has been studied by NMR spectroscopy. In DPC micelles, the cationic and hydrophilic N-terminal half of the peptide forms an S-shaped beta-sheet-like domain stabilized by a disulfide bridge and a few hydrogen bonds. This domain is followed by two alpha-helices: a hydrophilic 6-mer helix between residues 19 and 24 and an amphiphilic/hydrophobic 11-mer helix between residues 29 and 39. There are two hinges in the peptide, one at residues 16-18 between the N-terminal S-shaped beta-sheet-like structure and the central 6-mer helix and one at residues 26-28 between the central helix and the 11-mer C-terminal helix. The latter helix is the only amphiphilic/hydrophobic part of the peptide and is thus presumably the part that penetrates into the hydrophobic phase of target-cell membranes. The hinge between the two helices may introduce the flexibility that allows the helix to dip into membranes. The helix-hinge-helix structure in the C-terminal half of curvacin A clearly distinguishes this peptide from the other pediocin-like peptides whose structures have been analyzed and suggests that curvacin A along with the structural homologues enterocin P and carnobacteriocin BM1 belong to a subgroup of the pediocin-like family of antimicrobial peptides. | | The line below this paragraph, {{ABSTRACT_PUBMED_16331975}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16331975 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16331975}} |
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| ==About this Structure== | | ==About this Structure== |
| 2A2B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_curvatus Lactobacillus curvatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2B OCA]. | | 2A2B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_curvatus Lactobacillus curvatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2B OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Beta-sheet like strukture]] | | [[Category: Beta-sheet like strukture]] |
| [[Category: Peptide]] | | [[Category: Peptide]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:30:49 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:29:14 2008'' |
