2a5d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2a5d.gif|left|200px]]
{{Seed}}
[[Image:2a5d.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2a5d|  PDB=2a5d  |  SCENE=  }}  
{{STRUCTURE_2a5d|  PDB=2a5d  |  SCENE=  }}  


'''Structural basis for the activation of cholera toxin by human ARF6-GTP'''
===Structural basis for the activation of cholera toxin by human ARF6-GTP===




==Overview==
<!--
The Vibrio cholerae bacterium causes devastating diarrhea when it infects the human intestine. The key event is adenosine diphosphate (ADP)-ribosylation of the human signaling protein GSalpha, catalyzed by the cholera toxin A1 subunit (CTA1). This reaction is allosterically activated by human ADP-ribosylation factors (ARFs), a family of essential and ubiquitous G proteins. Crystal structures of a CTA1:ARF6-GTP (guanosine triphosphate) complex reveal that binding of the human activator elicits dramatic changes in CTA1 loop regions that allow nicotinamide adenine dinucleotide (NAD+) to bind to the active site. The extensive toxin:ARF-GTP interface surface mimics ARF-GTP recognition of normal cellular protein partners, which suggests that the toxin has evolved to exploit promiscuous binding properties of ARFs.
The line below this paragraph, {{ABSTRACT_PUBMED_16099990}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16099990 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16099990}}


==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Neal, C J.O.]]
[[Category: Neal, C J.O.]]
[[Category: Protein transport/transferase]]
[[Category: Protein transport/transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:37:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:15:47 2008''

Revision as of 09:16, 29 July 2008

File:2a5d.png

Template:STRUCTURE 2a5d

Structural basis for the activation of cholera toxin by human ARF6-GTP

Template:ABSTRACT PUBMED 16099990

About this Structure

2A5D is a Protein complex structure of sequences from Homo sapiens and Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

Structural basis for the activation of cholera toxin by human ARF6-GTP., O'Neal CJ, Jobling MG, Holmes RK, Hol WG, Science. 2005 Aug 12;309(5737):1093-6. PMID:16099990

Page seeded by OCA on Tue Jul 29 12:15:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2a5d&oldid=740776"