2a5x: Difference between revisions

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[[Image:2a5x.gif|left|200px]]
{{Seed}}
[[Image:2a5x.png|left|200px]]


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{{STRUCTURE_2a5x|  PDB=2a5x  |  SCENE=  }}  
{{STRUCTURE_2a5x|  PDB=2a5x  |  SCENE=  }}  


'''Crystal Structure of a Cross-linked Actin Dimer'''
===Crystal Structure of a Cross-linked Actin Dimer===




==Overview==
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The 2.5-A resolution crystal structure is reported for an actin dimer, composed of two protomers cross-linked along the longitudinal (or vertical) direction of the F-actin filament. The crystal structure provides an atomic resolution view of a molecular interface between actin protomers, which we argue represents a near-native interaction in the F-actin filament. The interaction involves subdomains 3 and 4 from distinct protomers. The atomic positions in the interface visualized differ by 5-10 A from those suggested by previous models of F-actin. Such differences fall within the range of uncertainties allowed by the fiber diffraction and electron microscopy methods on which previous models have been based. In the crystal, the translational arrangement of protomers lacks the slow twist found in native filaments. A plausible model of F-actin can be constructed by reintroducing the known filament twist, without disturbing significantly the interface observed in the actin dimer crystal.
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{{ABSTRACT_PUBMED_16141336}}


==About this Structure==
==About this Structure==
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Structural protein]]
[[Category: Structural protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:38:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:20:44 2008''

Revision as of 14:20, 28 July 2008

File:2a5x.png

Template:STRUCTURE 2a5x

Crystal Structure of a Cross-linked Actin Dimer

Template:ABSTRACT PUBMED 16141336

About this Structure

2A5X is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin., Kudryashov DS, Sawaya MR, Adisetiyo H, Norcross T, Hegyi G, Reisler E, Yeates TO, Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13105-10. Epub 2005 Sep 1. PMID:16141336

Page seeded by OCA on Mon Jul 28 17:20:44 2008

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