2a79: Difference between revisions

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[[Image:2a79.gif|left|200px]]
{{Seed}}
[[Image:2a79.png|left|200px]]


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{{STRUCTURE_2a79|  PDB=2a79  |  SCENE=  }}  
{{STRUCTURE_2a79|  PDB=2a79  |  SCENE=  }}  


'''Mammalian Shaker Kv1.2 potassium channel- beta subunit complex'''
===Mammalian Shaker Kv1.2 potassium channel- beta subunit complex===




==Overview==
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Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase beta subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit.
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{{ABSTRACT_PUBMED_16002581}}


==About this Structure==
==About this Structure==
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[[Category: Voltage dependent]]
[[Category: Voltage dependent]]
[[Category: Voltage sensor]]
[[Category: Voltage sensor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:41:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:14:00 2008''

Revision as of 23:14, 28 July 2008

File:2a79.png

Template:STRUCTURE 2a79

Mammalian Shaker Kv1.2 potassium channel- beta subunit complex

Template:ABSTRACT PUBMED 16002581

About this Structure

2A79 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel., Long SB, Campbell EB, Mackinnon R, Science. 2005 Aug 5;309(5736):897-903. Epub 2005 Jul 7. PMID:16002581

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