2a9i: Difference between revisions

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~~'''~~Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain~~'''~~

===Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain===

~~==Overview==~~

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IL-1R-~~associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved~~ the ~~crystal structure for~~ the ~~death domain of Mus musculus IRAK-4 to 1~~.~~7 A resolution~~. ~~This~~ is the ~~first glimpse of the structural details of a mammalian IRAK family member~~. ~~The crystal structure reveals a six~~-~~helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK~~-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.

The line below this paragraph, {{ABSTRACT_PUBMED_16177054}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16177054 is the PubMed ID number.

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==About this Structure==

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[[Category: Nair, S K.]]

[[Category: Hexahelical bundle]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:46:53 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:58:59 2008''

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-[[Image:2a9i.gif|left|200px]]
+{{Seed}}
+[[Image:2a9i.png|left|200px]]
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 {{STRUCTURE_2a9i|  PDB=2a9i  |  SCENE=  }}
-'''Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain'''
+===Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain===
-==Overview==
+<!--
-IL-1R-associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is the first glimpse of the structural details of a mammalian IRAK family member. The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.
+The line below this paragraph, {{ABSTRACT_PUBMED_16177054}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16177054 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16177054}}
 ==About this Structure==
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 [[Category: Nair, S K.]]
 [[Category: Hexahelical bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:46:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:58:59 2008''