2adc: Difference between revisions

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[[Image:2adc.gif|left|200px]]
{{Seed}}
[[Image:2adc.png|left|200px]]


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{{STRUCTURE_2adc|  PDB=2adc  |  SCENE=  }}  
{{STRUCTURE_2adc|  PDB=2adc  |  SCENE=  }}  


'''Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA'''
===Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA===




==Overview==
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The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.
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{{ABSTRACT_PUBMED_16179478}}


==About this Structure==
==About this Structure==
2ADC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADC OCA].  
2ADC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADC OCA].  


==Reference==
==Reference==
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[[Category: Rbd]]
[[Category: Rbd]]
[[Category: Rrm]]
[[Category: Rrm]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:54:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:06:28 2008''

Revision as of 11:06, 28 July 2008

File:2adc.png

Template:STRUCTURE 2adc

Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA

Template:ABSTRACT PUBMED 16179478

About this Structure

2ADC is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of PTB bound to RNA: specific binding and implications for splicing regulation., Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH, Science. 2005 Sep 23;309(5743):2054-7. PMID:16179478

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