2aho: Difference between revisions

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[[Image:2aho.gif|left|200px]]
{{Seed}}
[[Image:2aho.png|left|200px]]


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{{STRUCTURE_2aho|  PDB=2aho  |  SCENE=  }}  
{{STRUCTURE_2aho|  PDB=2aho  |  SCENE=  }}  


'''Structure of the archaeal initiation factor eIF2 alpha-gamma heterodimer from Sulfolobus solfataricus complexed with GDPNP'''
===Structure of the archaeal initiation factor eIF2 alpha-gamma heterodimer from Sulfolobus solfataricus complexed with GDPNP===




==Overview==
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Eukaryotic and archaeal initiation factors 2 (e/aIF2) are heterotrimeric proteins (alphabetagamma) supplying the small subunit of the ribosome with methionylated initiator tRNA. This study reports the crystallographic structure of an aIF2alphagamma heterodimer from Sulfolobus solfataricus bound to Gpp(NH)p-Mg(2+). aIF2gamma is in a closed conformation with the G domain packed on domains II and III. The C-terminal domain of aIF2alpha interacts with domain II of aIF2gamma. Conformations of the two switch regions involved in GTP binding are similar to those encountered in an EF1A:GTP:Phe-tRNA(Phe) complex. Comparison with the EF1A structure suggests that only the gamma subunit of the aIF2alphagamma heterodimer contacts tRNA. Because the alpha subunit markedly reinforces the affinity of tRNA for the gamma subunit, a contribution of the alpha subunit to the switch movements observed in the gamma structure is considered.
The line below this paragraph, {{ABSTRACT_PUBMED_16407071}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16407071}}


==About this Structure==
==About this Structure==
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[[Category: Yatime, L.]]
[[Category: Yatime, L.]]
[[Category: Initiation of translation]]
[[Category: Initiation of translation]]
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