2aip: Difference between revisions

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[[Image:2aip.gif|left|200px]]
{{Seed}}
[[Image:2aip.png|left|200px]]


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{{STRUCTURE_2aip|  PDB=2aip  |  SCENE=  }}  
{{STRUCTURE_2aip|  PDB=2aip  |  SCENE=  }}  


'''Crystal structure of native protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix'''
===Crystal structure of native protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix===




==Overview==
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Protein C activation initiated by the thrombin-thrombomodulin complex forms the major physiological anticoagulant pathway. Agkistrodon contortrix contortrix protein C activator, a glycosylated single-chain serine proteinase, activates protein C without relying on thrombomodulin. The crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator determined at 1.65 and 1.54 A resolutions, respectively, indicate the pivotal roles played by the positively charged belt and the strategic positioning of the three carbohydrate moieties surrounding the catalytic site in protein C recognition, binding, and activation. Structural changes in the benzamidine-inhibited enzyme suggest a probable function in allosteric regulation for the anion-binding site located in the C-terminal extension, which is fully conserved in snake venom serine proteinases, that preferentially binds Cl(1-) instead of SO(4)(2-).
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{{ABSTRACT_PUBMED_16162508}}


==About this Structure==
==About this Structure==
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[[Category: Snake venom]]
[[Category: Snake venom]]
[[Category: Trypsin-like enzyme]]
[[Category: Trypsin-like enzyme]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:05:56 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:42:33 2008''

Revision as of 10:42, 29 July 2008

File:2aip.png

Template:STRUCTURE 2aip

Crystal structure of native protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix

Template:ABSTRACT PUBMED 16162508

About this Structure

2AIP is a Single protein structure of sequence from Agkistrodon contortrix contortrix. Full crystallographic information is available from OCA.

Reference

Thrombomodulin-independent activation of protein C and specificity of hemostatically active snake venom serine proteinases: crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator., Murakami MT, Arni RK, J Biol Chem. 2005 Nov 25;280(47):39309-15. Epub 2005 Sep 14. PMID:16162508

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