2dyn: Difference between revisions

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[[Image:2dyn.gif|left|200px]]<br />

[[Image:2dyn.gif|left|200px]]<br /><applet load="2dyn" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2dyn" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2dyn, resolution 2.30Å" />

'''DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)'''<br />

==Overview==

The pleckstrin homology (PH) domain is a conserved module present in many, signal transducing and cytoskeletal proteins. Here we report the 2.8 A, crystal structure of the PH domain from dynamin. This domain consists of, seven beta-strands forming two roughly orthogonal antiparallel beta-sheets, terminating with an amphipathic alpha-helix. The structure also reveals a, non-covalent dimeric association of the PH domain and a hydrophobic pocket, surrounded by a charged rim. The dynamin PH domain structure is discussed, in relation to its potential role in mediating interactions between, proteins.

The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins.

==Disease==

Known diseases associated with this structure: ~~Charcot-Marie-Tooth disease~~, ~~dominant intermediate B OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602378 602378]], Myopathy~~, ~~centronuclear~~ OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=~~602378 602378~~]]

Known diseases associated with this structure: Encephalopahty, lethal, due to defective mitochondrial peroxisomal fission OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603850 603850]]

==About this Structure==

2DYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA].

2DYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Timm, D.E.]]

[[Category: Timm, D E.]]

[[Category: motor protein]]

[[Category: phospholipid binding]]

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[[Category: signal transduction]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12~~ 21:40:~~58 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:04:07 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2dyn.gif|left|200px]]<br />
+[[Image:2dyn.gif|left|200px]]<br /><applet load="2dyn" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2dyn" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2dyn, resolution 2.30&Aring;" />
 '''DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)'''<br />
 ==Overview==
-The pleckstrin homology (PH) domain is a conserved module present in many, signal transducing and cytoskeletal proteins. Here we report the 2.8 A, crystal structure of the PH domain from dynamin. This domain consists of, seven beta-strands forming two roughly orthogonal antiparallel beta-sheets, terminating with an amphipathic alpha-helix. The structure also reveals a, non-covalent dimeric association of the PH domain and a hydrophobic pocket, surrounded by a charged rim. The dynamin PH domain structure is discussed, in relation to its potential role in mediating interactions between, proteins.
+The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins.
 ==Disease==
-Known diseases associated with this structure: Charcot-Marie-Tooth disease, dominant intermediate B OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602378 602378]], Myopathy, centronuclear OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602378 602378]]
+Known diseases associated with this structure: Encephalopahty, lethal, due to defective mitochondrial peroxisomal fission OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603850 603850]]
 ==About this Structure==
-DYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA].
+DYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Timm, D.E.]]
+[[Category: Timm, D E.]]
 [[Category: motor protein]]
 [[Category: phospholipid binding]]
@@ Line 23: / Line 22: @@
 [[Category: signal transduction]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:40:58 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:04:07 2008''