2auk: Difference between revisions

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[[Image:2auk.~~gif~~|left|200px]]

[[Image:2auk.png|left|200px]]

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~~'''~~Structure of E. coli RNA polymerase beta' G/G' insert~~'''~~

===Structure of E. coli RNA polymerase beta' G/G' insert===

~~==Overview==~~

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The ~~large beta and beta' subunits of the bacterial core RNA polymerase (RNAP) are highly conserved throughout evolution. Nevertheless~~, large sequence insertions in beta and beta' characterize specific evolutionary lineages of bacteria. The Thermus aquaticus RNAP beta' subunit contains a 283 residue insert between conserved regions A and B that is found in only four bacterial species. The Escherichia coli RNAP beta' subunit contains a 188 residue insert in the middle of conserved region G that is found in a wide range of bacterial species. Here, ~~we present structural studies of these two beta' insertions. We show that~~ the ~~inserts comprise repeats of a previously characterized fold,~~ the ~~sandwich-barrel hybrid motif~~ (as ~~predicted from previous sequence analysis~~) ~~and that~~ the ~~inserts serve significant roles in facilitating protein/protein and/or protein/nucleic acid interactions~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16154587}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16154587 is the PubMed ID number.

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==About this Structure==

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[[Category: Nikiforov, V.]]

[[Category: Sandwich-barrel hybrid motif]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 19~~:29:33 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:59:59 2008''

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-[[Image:2auk.gif|left|200px]]
+{{Seed}}
+[[Image:2auk.png|left|200px]]
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 {{STRUCTURE_2auk|  PDB=2auk  |  SCENE=  }}
-'''Structure of E. coli RNA polymerase beta' G/G' insert'''
+===Structure of E. coli RNA polymerase beta' G/G' insert===
-==Overview==
+<!--
-The large beta and beta' subunits of the bacterial core RNA polymerase (RNAP) are highly conserved throughout evolution. Nevertheless, large sequence insertions in beta and beta' characterize specific evolutionary lineages of bacteria. The Thermus aquaticus RNAP beta' subunit contains a 283 residue insert between conserved regions A and B that is found in only four bacterial species. The Escherichia coli RNAP beta' subunit contains a 188 residue insert in the middle of conserved region G that is found in a wide range of bacterial species. Here, we present structural studies of these two beta' insertions. We show that the inserts comprise repeats of a previously characterized fold, the sandwich-barrel hybrid motif (as predicted from previous sequence analysis) and that the inserts serve significant roles in facilitating protein/protein and/or protein/nucleic acid interactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_16154587}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16154587 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16154587}}
 ==About this Structure==
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 [[Category: Nikiforov, V.]]
 [[Category: Sandwich-barrel hybrid motif]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:29:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:59:59 2008''