2auz: Difference between revisions

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[[Image:2auz.~~gif~~|left|200px]]

[[Image:2auz.png|left|200px]]

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~~'''~~Cathepsin K complexed with a semicarbazone inhibitor~~'''~~

===Cathepsin K complexed with a semicarbazone inhibitor===

~~==Overview==~~

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~~Starting from potent aldehyde inhibitors with poor drug properties~~, ~~derivatization to semicarbazones led~~ to the ~~identification of a series of semicarbazone-based cathepsin K inhibitors with greater solubility and better pharmacokinetic profiles than their parent aldehydes~~. ~~Furthermore, a representative semicarbazone inhibitor attenuated bone resorption in an ex vivo rat calvarial bone resorption model~~. ~~However~~, ~~based on enzyme inhibition comparisons at neutral pH, semicarbazone hydrolysis rates, and 13C NMR experiments, these semicarbazones probably function as prodrugs of aldehydes~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16290936}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16290936 is the PubMed ID number.

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==About this Structure==

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[[Category: Catk]]

[[Category: Cysteine protease]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 19~~:30:30 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:12:09 2008''

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-[[Image:2auz.gif|left|200px]]
+{{Seed}}
+[[Image:2auz.png|left|200px]]
 <!--
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 {{STRUCTURE_2auz|  PDB=2auz  |  SCENE=  }}
-'''Cathepsin K complexed with a semicarbazone inhibitor'''
+===Cathepsin K complexed with a semicarbazone inhibitor===
-==Overview==
+<!--
-Starting from potent aldehyde inhibitors with poor drug properties, derivatization to semicarbazones led to the identification of a series of semicarbazone-based cathepsin K inhibitors with greater solubility and better pharmacokinetic profiles than their parent aldehydes. Furthermore, a representative semicarbazone inhibitor attenuated bone resorption in an ex vivo rat calvarial bone resorption model. However, based on enzyme inhibition comparisons at neutral pH, semicarbazone hydrolysis rates, and 13C NMR experiments, these semicarbazones probably function as prodrugs of aldehydes.
+The line below this paragraph, {{ABSTRACT_PUBMED_16290936}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16290936 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16290936}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Catk]]
 [[Category: Cysteine protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:30:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:12:09 2008''