2avu: Difference between revisions

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[[Image:2avu.gif|left|200px]]
{{Seed}}
[[Image:2avu.png|left|200px]]


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{{STRUCTURE_2avu|  PDB=2avu  |  SCENE=  }}  
{{STRUCTURE_2avu|  PDB=2avu  |  SCENE=  }}  


'''Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription'''
===Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription===




==Overview==
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The hetero-oligomeric complex of the FlhD and FlhC proteins (FlhDC) regulates transcription from several flagellar and non-flagellar operons in bacteria. The crystallographic structure of the Escherichia coli FlhDC complex has been solved to 3.0 A resolution, revealing a hexameric FlhD4FlhC2 assembly. In the complex, each FlhC protomer binds an FlhD2 dimer; the conformation of the dimer in the complex differs significantly from its conformation in the absence of FlhC. FlhC has a novel tertiary fold that includes a heretofore unrecognized zinc-binding site in which the ion is ligated by four cysteine residues. Gel shift experiments show that binding of the FlhDC complex to a cognate promoter bends the DNA by approximately 111 degrees . The structure of the FlhDC complex is compatible with models in which a fragment of operator DNA, at least 48 base-pairs in length, wraps around the complex and bends significantly when binding.
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{{ABSTRACT_PUBMED_16337229}}


==About this Structure==
==About this Structure==
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[[Category: Westbrook, E M.]]
[[Category: Westbrook, E M.]]
[[Category: C4-type zinc finger]]
[[Category: C4-type zinc finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:31:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:14:01 2008''

Revision as of 03:14, 29 July 2008

File:2avu.png

Template:STRUCTURE 2avu

Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription

Template:ABSTRACT PUBMED 16337229

About this Structure

2AVU is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription., Wang S, Fleming RT, Westbrook EM, Matsumura P, McKay DB, J Mol Biol. 2006 Jan 27;355(4):798-808. Epub 2005 Nov 22. PMID:16337229

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