2ax0: Difference between revisions

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[[Image:2ax0.gif|left|200px]]
{{Seed}}
[[Image:2ax0.png|left|200px]]


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{{STRUCTURE_2ax0|  PDB=2ax0  |  SCENE=  }}  
{{STRUCTURE_2ax0|  PDB=2ax0  |  SCENE=  }}  


'''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)'''
===Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)===




==Overview==
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Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several of these inhibitors and HCV NS5b were determined by X-ray crystallography, and the inhibitors were found to bind in an allosteric binding site separate from the active site. Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b.
The line below this paragraph, {{ABSTRACT_PUBMED_16451069}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16451069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16451069}}


==About this Structure==
==About this Structure==
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[[Category: Polymerase]]
[[Category: Polymerase]]
[[Category: Thumb]]
[[Category: Thumb]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:34:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:26:56 2008''
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