2axu: Difference between revisions

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[[Image:2axu.gif|left|200px]]
{{Seed}}
[[Image:2axu.jpg|left|200px]]


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{{STRUCTURE_2axu|  PDB=2axu  |  SCENE=  }}  
{{STRUCTURE_2axu|  PDB=2axu  |  SCENE=  }}  


'''Structure of PrgX'''
===Structure of PrgX===




==Overview==
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Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production of antibiotics, are controlled by intercellular signaling using small molecules. To date, understanding of the molecular mechanisms of peptide-mediated cell-cell signaling has been limited by a dearth of published information about the molecular structures of the signaling components. Here, we present the molecular structure of PrgX, a DNA- and peptide-binding protein that regulates expression of the conjugative transfer genes of the Enterococcus faecalis plasmid pCF10 in response to an intercellular peptide pheromone signal. Comparison of the structures of PrgX and the PrgX/pheromone complex suggests that pheromone binding destabilizes PrgX tetramers, opening a 70-bp pCF10 DNA loop required for conjugation repression.
The line below this paragraph, {{ABSTRACT_PUBMED_16339309}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16339309 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16339309}}


==About this Structure==
==About this Structure==
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[[Category: Pheromone]]
[[Category: Pheromone]]
[[Category: Repressor]]
[[Category: Repressor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:36:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:02:18 2008''
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