2ayp: Difference between revisions

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[[Image:2ayp.gif|left|200px]]
{{Seed}}
[[Image:2ayp.png|left|200px]]


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{{STRUCTURE_2ayp|  PDB=2ayp  |  SCENE=  }}  
{{STRUCTURE_2ayp|  PDB=2ayp  |  SCENE=  }}  


'''Crystal Structure of CHK1 with an Indol Inhibitor'''
===Crystal Structure of CHK1 with an Indol Inhibitor===




==Overview==
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Chk1 inhibitors have emerged as a novel class of neoplastic agents for abrogating the G2 DNA damage checkpoint arrest. Analogs of the Chk1 inhibitor, 3-ethylidene-1,3-dihydro-indol-2-one, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 28, which possesses potent enzymatic and cellular activities.
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{{ABSTRACT_PUBMED_16242328}}


==About this Structure==
==About this Structure==
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[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:38:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:26:26 2008''

Revision as of 04:26, 28 July 2008

File:2ayp.png

Template:STRUCTURE 2ayp

Crystal Structure of CHK1 with an Indol Inhibitor

Template:ABSTRACT PUBMED 16242328

About this Structure

2AYP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors., Lin NH, Xia P, Kovar P, Park C, Chen Z, Zhang H, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. Epub 2005 Oct 18. PMID:16242328

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